key_buffer_size

Index blocks for MyISAM tables are buffered and are shared by all threads. key_buffer_size is the size of the buffer used for index blocks. The key buffer is also known as the key cache.

table_cache

The number of open tables for all threads. Increasing this value increases the number of file descriptors that mysqld requires. You can check whether you need to increase the table cache by checking the Opened_tables status variable.

http://dev.mysql.com/doc/refman/5.0/en/server-parameters.html